Contents
Vacuum film coating is a new coating procedure that employs a specially designed baffled pan. The pan is hot water-jacketed, and it can be sealed to achieve a vacuum system.
The tablets are placed in the sealed pan, and the air in the pan is displaced by nitrogen before the desired vacuum level is obtained. The coating solution is then applied with an airless spray system. The heated pan causes evaporation, and the vapor is removed by the vacuum system.
Because there is no high-velocity heated air, the energy requirement is low, and coating efficiency is high. Organic solvent can be effectively used with this coating system with minimum environmental or safety concerns.
This can be applied as one homogeneous layer, which can be white–opaque or colored. The advantage is that only one application is needed.
In a two-layer system, the enteric formulation is applied first, followed by colored film. Both layers can be of enteric polymer, or only the basic layer can contain enteric polymer while the top layer is a fast disintegrating and water-soluble polymer.
Read more on Enteric Coating
Dip coating is a famous way of creating thin films for research functions. The coating material is applied to the tablet cores by dipping them into the coating liquid.
The wet tablets are dried in a conventional manner in a coating pan. Alternative dipping and drying steps may be repeated several times to obtain the desired coating.
This process lacks the speed, versatility, and reliability of spray-coating techniques. Specialized equipment has been developed to dip coat tablets, but no commercial pharmaceutical application has been obtained.
Supercell coating technology is a revolutionary tablet coating that accurately deposits controlled amounts of coating materials on tablets – even if they are extremely hygroscopic or friable. This technique may be used for coating flat or highly oblong tablets or friable tablets.
In this process, drying is very fast, making it possible to coat extremely hygroscopic tablets. The deposition accuracy is sufficiently high to layer drug substance onto tablets, and uniform layers of taste masking or modified release coatings can be applied consecutively within a single continuous batch.
Some of the unique features of supercell coating technology are:
OSDrC® is an innovative first-of-its-kind manufacturing process and variable double-punch tableting technology that opens the door to a new world of pharmaceutical tablet manufacturing. By simply changing the punch, product development scientists can create new formulations and tablet configurations not possible with current manufacturing technology.
The OSDrC® rotary tableting machine, with its variable double-punch configuration, supports single-step manufacturing of pharmaceutical products. In addition to the commercial-scale production of conventional cored (tablet-within-a-tablet) tablets, this machine is ideal for manufacturing a variety of high-quality drug products at low cost. This innovative technology can also replace conventional sugar- and film-coated tablets.
OSDrC® allows placement of any number of cores of any shape into the tablet just where they need to be positioned for optimum delivery of active pharmaceutical ingredients (API). Misaligned cores are a thing of the past. This paves the way for high value-added drug formulation development, such as divided tablets with two cores, pulsatile tablets with three cores, and combination products.
OSDrC® technology also allows incorporation of core ingredients with poor compressibility, such as magnesium stearate. OSDrC® tablets with pellets as their core can replace conventional capsules. OSDrC® paves the way for development of various novel drug formulations, such as new oral rapid disintegration tablets.
Despite the fact that the top spray fluid mattress system is extensively used for granulation its use for coating is restrained. Top spraying is the most effective method and gives the best capability and lowest capital cost.
It could be used for numerous manipulations of taste covering and many others. This method alternative is often used in the food, feed, and chemical industries as the characteristic of the film mainly serves to enhance the general managing situations.
The maximum normally recognized fluid-bed system for coating inside the pharmaceutical
industry is bottom-spray technique. The precise functions of bottom-spraying are an air
distributes plate and a partition that arrange fluidization of particles of debris via the partition.
The nozzle is installed at the bottom of the product box and is focused in the coating zone.
Tablet coating techniques
